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pentobarbital will reduce the level or outcome of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can cut down panobinostat concentrations by ~70% and bring about